Difference between functional genomics and bioinformatics?

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Difference between functional genomics and bioinformatics?

Postby Kashfia » Sat Feb 20, 2016 2:18 am


Can anyone elaborate the difference between 'functional genomics' and bioinformatics? In the university websites I can see they have graduate programs in these two fields. But when I search online the two words is coming up together.

I would really appreciate if anyone can help in this purpose.

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Re: Difference between functional genomics and bioinformatics?

Postby PACN » Mon Feb 22, 2016 3:46 pm

Bioinformatics is broader than genomics-- it is anything that involves analyzing and understanding large data sets within biology. As such, in addition to genomics, it could encompass other -omics (proteomics, metabolomics), as well as health care research, patient outcomes research, etc. So I would say that functional genomics is probably a subset of bioinformatics.
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Re: Difference between functional genomics and bioinformatics?

Postby MDM » Tue Feb 23, 2016 2:38 pm

Functional genomics is concerned with using technologies like RNA interference, gene editing, and other means of gene modulation (knockdown, upregulation, knockout/knock-in, etc.) to see what kind of phenotypic effect it has in order to elucidate a gene's functional role. If you do this on a large-scale, such as a genome-wide RNAi screen, then you'll probably use bioinformatics for the analysis. Functional genomics and bioinformatics often go hand-in-hand, but they are definitely not the same thing. Functional genomics people are usually in the lab at the bench, bioinformaticians are usually not and are computational. The two will likely need to work closely together.
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