After 46 years in cardiology and clinical research, I'm finding it difficult to understand why Alzheimers research continues to try to find ways to prevent the disease when the treatment has been stagnant for decades. If prevention is unreachable at this time and new studies are falling by the wayside, industry is understandably reluctant to keep trying. So many diseases are now treatable while the search continues to try to find the cause-atherosclerosis, diabetes, cancer. The meager positive outcomes in pre, mild and moderate improvement are so subjective as to make them unreliable as a template for success. Now with a family member nearing death, I am here to tell you that the back end is where efforts will make a difference. Someone who is not moderate to severe is not yet a complete burden on the family and caregivers and the major financial losses are just starting at this stage. Lifetimes of hopes and dreams are slowly and completely destroyed. Most survivors will never be able to recover physically, mentally, financially.
I have searched for years for studies that include the later stages. I don't understand why they have not been included. When you are desperate there are no adverse events. Phase 1 studies would fill rapidly. As with cancer and AIDES there is no clamor from families to try a drug, any drug that may work because they are too tired to clamor.